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Laboratory Safety Manual

Special Procedures

Special procedures must be developed for work involving materials

or equipment that present a significant risk of exposure or injury

to the human body. Examples include carcinogens, reproductive

toxins, teratogens, highly toxic substances, explosives, controlled

substances, select biological agents, radioactive materials, radiation

producing devices, and lasers. The following special procedures must

be developed and specified on the


Identify authorized personnel

who are permitted to work with

these materials or equipment. Authorized persons must receive

training on the unique hazards of these materials or equipment

before use.

Establish a designated area for a specific use

(e.g., fume

hood, glove box, lab bench, etc.) and identify the area by signs

or postings. Restrict access to this area to authorized personnel.

If an entire laboratory is designated, then access must be

restricted to authorized personnel.

Specify special safety precautions

for experiments or

laboratory operations where these materials or equipment are

used. Be sure to identify specialized equipment, shielding, or

security requirements to be used.

Additional Resources

Carcinogens, Reproductive Toxins and Teratogens

Laser Safety Manual

Radiation Safety Manual

Sealed Source Safety Manual

Select Biological Agents

Use of Engineering Controls

Engineering controls must be implemented where and when possible

to reduce hazards associated with the use and storage of chemical,

biological, and radiological materials. Engineering controls should be

considered in the following order:

• substitution of less hazardous equipment, chemicals, or


• physical isolation of the operator or process

• local and general exhaust ventilation and/or filtration (e.g., use


fume hoods ,

charcoal filters, etc.)

Note –

Many of these

materials or equipment

require special authorization

from EH&S or a government

agency to purchase,

possess and use. Refer to

the “Ordering Chemical,

Biological and Radioactive

Materials” Section below

for information on the

application process for each