9 Biosafety Manual Institutional Biosafety Committee (IBC) The IBC is appointed by the Office of the Vice President of Research and serves as the review committee in all matters involving recombinant or synthetic nucleic acid molecules studies, as required by the National Institutes of Health’s (NIH) Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules (NIH Guidelines). The IBC is responsible for reviewing the biological safety and public health programs at ISU, including: • any use of human, animal, or plant pathogens or biological toxins, • administration of experimental biological products (vaccines, sera, etc.) to animals, and • field releases of plant pests or genetically engineered organisms. The IBC also makes policy recommendations to the Office of the Vice President for Research to ensure compliance with federal, state and local regulations and guidelines. The IBC has the authority to require operational changes to ensure compliance with required conditions.