11 Radioactive Materials Safety Manual Environmental Health and Safety University Compliance Committees Iowa State University’s compliance program includes conflict of interest, research integrity, export control, and research compliance review committees. The purpose of the compliance review committees is to review and approve all relevant proposals to ensure that they are in compliance with university, local, state, federal, and funding agency regulations for research. The four review committees administratively reside within the Office of Research Ethics (ORE) and include: Animals - Institutional Animal Care and Use Committee (IACUC) All activities involving the use of live vertebrate animals must be approved by the IACUC prior to the use of the animals in research or teaching activities. Research activities include field studies, clinical trials, the use of blood donor animals, and breeding colonies. Teaching activities include scheduled courses and continuing education offerings. Biohazards - Institutional Biosafety Committee (IBC) The IBC must approve any teaching or research project that involves: the use of recombinant or synthetic nucleic acid molecules including transgenic animals or plants; the use of human, animal, or plant pathogens (e.g., bacteria, viruses, prions, parasites); the use of biological toxins; materials received under the USDA APHIS permit the administration of experimental biological products to animals; or field releases of plant pests or genetically modified organisms (GMO). Humans - Institutional Review Board (IRB) The IRB reviews any research involving human participants, including proposals to gather data from participants for theses, dissertations, and other student projects. Radiation - Radiation Safety Committee (RSC) All research using radiation must be approved by the RSC. IRB, IACUC and IBC applications using radiation must be reviewed and approved by the RSC, as these committees do not have the authority to approve radiation use.